Saturday, December 31, 2011

For stock market in 2011, the world was flat

Stock market, as measured by the S&P 500, ends the year just as it started. But stock market in fourth quarter staged an impressive rally, which could set the tone for 2012. ?

The stock market ended a tumultuous year right where it started.

Skip to next paragraph

In the final tally, despite big climbs and falls, unexpected blows and surprising triumphs, all the hullabaloo proved for naught. On Friday, the Standard & Poor's 500 index closed at 1,257.60. That's exactly 0.04 point below where it started the year.

"If you fell asleep January 1 and woke up today, you'd think nothing had happened," says Jack Ablin, chief investment officer of Harris Private Bank. "But it's been up and down all year. It's been crazy."

It was a year when U.S. companies were supposed to run out of ways to make big profits. But they didn't, and in fact generated more than ever. It was a year when the U.S. lost its prized triple-A credit rating, which should have spooked buyers of its bonds. Instead investors bought more of them and made Treasurys one of the best bets of 2011. It was a year when stocks caught fire, then collapsed to near bear-market lows.

Among stocks, there were some surprising winners. Scaredy-cat investors who bought the most conservative and dullest of stocks ? utilities ? gained 15 percent this year, the biggest price rise of the ten industry sectors in the S&P 500. Other winning groups were consumer staples, up 11 percent, and health care companies, 10 percent.

Other market curiosities:

? Bad year, great quarter. Despite disappointing returns in 2011, the last three months of the year were impressive, which could bode well for the new year. The S&P 500 rose 11 percent. The Dow Jones industrial average, comprising 30 big stocks, climbed 1,344 points, or 12 percent. That was the largest quarterly point gain in its history. The Dow closed up 5.5 percent for the year.

? Best of the bad. U.S. stocks delivered little this year, but other markets did even worse, including ones in fast-growing economies. Brazil's Bovespa index fell 18 percent in 2011. Hong Kong's Hang Seng dropped 20 percent. In Europe, many of the biggest markets ended down in 2011. Britain's FTSE 100 lost 5.6 percent, Germany's DAX 14.7 percent.

? Buy American is back. A broad index of the Treasury market gained 9.6 percent, despite the fact that the U.S. government is now slightly less likely to repay its debt, at least according to Standard & Poor's. In August, the rating agency stripped the U.S. of its triple-A rating, citing mounting U.S. debt and political squabbling over what to do about it.

For stock investors, 2011 wasn't supposed to end this way.

At the start of the year, the Great Recession was officially 1? years behind us and the recovery was finally gaining momentum. The economy added an average of more than 200,000 jobs a month in February, March and April. And U.S. companies kept reporting big jumps in profits, defying naysayers.

The stock market roared in approval. On April 29, the S&P closed at 1,363, double its recessionary low of March 2009.

Then manufacturing slowed, companies stopped hiring and consumer confidence plummeted, taking with it those hopes of big stock gains for the year. Adding to the misery, Japan was rocked by an earthquake and tsunami. That shut down factories run by crucial parts suppliers to U.S. firms, in particular auto makers.

Gridlock in Washington didn't help. After much squabbling, politicians eventually decided to raise the cap on how much the federal government can borrow in early August. But the heated debate took its toll. The Dow Jones industrial average swung more than 400 points four days in a row ? down and up and down and up.

Overhanging it all was fear that the debt crisis in Greece had spread to Italy and Spain, countries too large for other European nations to bail out.

Talk of another blockbuster year for stocks turned to dark musings about the possibility of another U.S. recession. And so stocks kept falling. On Oct. 3, stocks had dropped 19 percent from their April high. That was just one point short of an official bear market.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/Jh2YoKLglMQ/For-stock-market-in-2011-the-world-was-flat

occupy dc trisomy 18 oklahoma state farrah abraham whats going on venus williams bowl projections

Kim Jong Un Declared 'Supreme Leader' Of North Korea

PYONGYANG, North Korea -- North Korea declared Kim Jong Il's son and successor "supreme leader" of the ruling party, military and the people during a memorial Thursday for his father in the government's first public endorsement of his leadership.

Kim Jong Un, head bowed and somber in a dark overcoat, stood on a balcony at the Grand People's Study House overlooking Kim Il Sung Square watching the memorial, which also served as a show of support for North Korea's next leader. He was flanked by top party and military officials, including Kim Jong Il's younger sister, Kim Kyong Hui, and her husband Jang Song Thaek, who are expected to serve as mentors of their young nephew.

Given Kim Jong Un's inexperience and age ? he is in his late 20s ? there are questions outside North Korea about whether he is equipped to lead a nation engaged in long-stalled negotiations over its nuclear program and grappling with decades of economic hardship and chronic food shortages.

But support among North Korea's power brokers was unequivocal at the memorial service, attended by hundreds of thousands of people filling Kim Il Sung Square and other plazas in central Pyongyang.

"The fact that he completely resolved the succession matter is Great Comrade Kim Jong Il's most noble achievement," Kim Yong Nam, president of the Presidium of the Supreme People's Assembly, told the massive audience at the square.

"Respected Comrade Kim Jong Un is our party, military and country's supreme leader who inherits great comrade Kim Jong Il's ideology, leadership, character, virtues, grit and courage," said Kim, considered North Korea's ceremonial head of state.

Thursday's memorial "was an event to publicly reconfirm and solidify" Kim Jong Un's status, said Jeung Young-tae, an analyst with the Korea Institute for National Unification in Seoul, South Korea.

"Kim Jong Un is already the leader of the party, military and country," he said.

Life in the North Korean capital came to a standstill as a mourners blanketed the plaza from the Grand People's Study to the Taedong River for the second day of funeral ceremonies for the late leader.

Kim Jong Il, who led his 24 million people with absolute power for 17 years, died of a heart attack Dec. 17 at age 69, according to state media. He inherited power from his father, North Korea founder Kim Il Sung, who died of a heart attack in 1994, in what was the communist world's first hereditary succession.

Attention turned to Kim Jong Un after he was revealed last year as his father's choice among three known sons to carry the Kim dynasty into a third generation.

The process to groom him was rushed compared to the 20 years Kim Jong Il had to prepare to take over from his father, and relied heavily on the Kim family bloodline and legacy as guerrilla fighters and the nation's founders.

Kim Il Sung is North Korea's first and only president; he retains the title "Eternal President" even after his death.

Kim Jong Il held three main positions: chairman of the National Defense Commission, general secretary of the Workers' Party and supreme commander of the Korean People's Army.

According to the constitution, his position as chairman of the National Defense Commission makes him "supreme leader" of North Korea.

Kim Jong Un was made a four-star general last year and appointed a vice chairman of the Central Military Commission of the Workers' Party. Since his father's death, state media have bestowed on him a series of new titles signaling that his succession campaign was gaining momentum: Great Successor, Supreme Leader and Sagacious Leader.

"Kim Jong Il laid a red silk carpet, and Kim Jong Un only needs to walk on it," Jeung said.

Last weekend, the Workers' Party newspaper, Rodong Sinmun, called on the younger Kim to step into his father's role as supreme commander of the armed forces.

Kim also must formally assume command of the Workers' Party and become chairman of the party's Central Military Commission, said Yoo Ho-yeol, a professor at Korea University in South Korea.

The military will dedicate itself to protecting Kim Jong Un, the "supreme leader of our revolutionary armed forces," Gen. Kim Jong Gak, first vice director of the General Political Bureau of the Korean People's Army, said at the memorial.

The aftermath of Kim Jong Il's death has been watched closely for clues about who in the military and Workers' Party will form Kim's inner circle of trusted aides during the sensitive transition to leadership.

During the mourning period, the young Kim made at least five visits to his father's begonia-bedecked bier when the late leader was lying in state at the Kumsusan Memorial Palace, accompanied at times by his father's confidantes.

Following right behind Kim during a Wednesday funeral procession through Pyongyang streets with Kim Jong Il's hearse was his uncle, Jang Song Thaek, who is a vice chairman of the powerful National Defense Commission and has family ties to the military.

On the other side of the hearse was Ri Yong Ho, vice marshal of the Korean People's Army, and other top military officials.

Kim Jong Il's two other sons, Kim Jong Nam and Kim Jong Chol, were not spotted at either the funeral or memorial.

For Thursday's memorial, North Koreans packed the main square as well as the plaza in front of a Workers' Party monument of a hammer, sickle and writing brush.

Flags at half-staff fluttered in the wind on the cold winter's day, and people were bundled up in parkas. State TV showed a delegation of foreigners attending the memorial.

They bowed their heads as eight artillery guns fired; military officers removed their hats while the booms resonated across Kim Il Sung Square.

The streets went still again for a three-minute period of silence. Heads bowed, workers paused next to a green train and bystanders stopped where they were, some standing next to their bicycles, as trains and boats sirens blew their horns, according to state media.

___

Associated Press Korea bureau chief Jean H. Lee and writers Hyung-jin Kim, Foster Klug and Sam Kim in Seoul, South Korea, contributed to this report. Follow AP's North Korea coverage at twitter.com/newsjean, twitter.com/APklug and twitter.com/samkim_ap.

'; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/2011/12/29/kim-jong-un-north-korea_n_1173933.html

weather colorado springs weather colorado springs chaz bono tonight show tonight show unthink julianne hough

Dallas Mayor: No Iraq war parade, fold into Veterans Day parade

by BRAD WATSON

WFAA

Posted on December 29, 2011 at 7:21 PM

Updated today at 8:04 PM

DALLAS - The Iraq war is over.

It lasted nine years and took the lives of 418 Texans.

Yet the welcome home events so far have been small.

Days after the final troops leave Iraq, at Fort Hood and other Texas military installations, there are still no big local plans to honor the troops.

When those who served in the Gulf War returned in 1991, Dallas staged one of largest parades in the country.

Dallas Mayor Mike Rawlings told News 8 Thursday he's open to honoring those who fought, but not necessarily in a separate parade.

Twenty years ago, the Dallas Gulf War parade drew a crowd police estimated at more than 100,000.

But with Iraq free and American forces gone, Mayor Rawlings says he doesn't favor a separate parade this time.

He prefers to hold off until Dallas' Veterans Day parade in November, the nation's second-biggest, to honor those who served in Iraq.

"I would just like to take the next 10 months to make sure all the veterans are back here," Rawlings said. "Make it a region-wide parade, invite them all, let's do it right when we do it."

The 1991 parade relied on a volunteer committee to coordinate, with billionaire and civic leader Ross Perot behind the execution.

Hundreds volunteered for the events, which spanned three days and cost about $3 million.

Private donations covered one million, in-kind donations covered more, and the city picked up some security costs.

Public relations consultant John Weekley directed the '91 parade and would like to see one now.

"If we just did a parade and say, had a ceremony at Fair Park in the Cotton Bowl or someplace like that, you could probably do it for a couple of million dollars," Weekley said.

But times are different.

Rawlings said the city's budget is too strapped to pick up security, and the war continues in Afghanistan.

He's talked to the veterans' groups sponsoring the parade and says they're in.

"They think it's a great idea to make sure that that Veteran's Day parade really honors the Iraqi soldier, veteran and active soldiers as well," Rawlings said.

The Veterans Day parade is all privately funded, even for police security, the mayor says. The theme of last month's vets day parade was "Remembering Pearl Harbor."

Rawlings says in 2012, it can be honoring the service and sacrifice in Iraq.

E-mail bwatson@wfaa.com

Source: http://www.wfaa.com/news/local/Dallas-Mayor-No-Iraq-war-parade-fold-into-vets-day-parade-136403608.html

cyber monday 2011 turkey pot pie turkey pot pie southern university regenesis fanboys ucla usc

New Satellites to Extend China's Military Reach

China this week reached a milestone in its drive to master the military use of space with the launch of trials for its Beidou satellite global positioning network, a move that will bring it one step closer to matching U.S. space capabilities.

Getty Images

A Long March 2F rocket carrying the country's first space laboratory module Tiangong-1 lifts off from the Jiuquan Satellite Launch Center in September 2011.


If Beijing can successfully deploy the full 35 satellites planned for the Beidou network on schedule by 2020, its military will be free of its current dependence for navigation on the U.S. global positioning network (GPS) signals and Russia's similar GLONASS system.

And, unlike the less accurate civilian versions of GPS and GLONASS available to the People's Liberation Army (PLA), this network will give China the accuracy to guide missiles, smart munitions and other weapons.

"This will allow a big jump in the precision attack capability of the PLA," said Andrei Chang, a Hong Kong-based analyst of the Chinese military and editor of Kanwa Asian Defence magazine.

China has launched 10 Beidou satellites and plans to launch six more by the end of next year, according to the China Satellite Navigation Management Office.

Chinese and foreign military experts say the PLA's General Staff Department and General Armaments Department closely coordinate and support all of China's space programs within the sprawling science and aerospace bureaucracy.

As part of this system, the Beidou, or "Big Dipper", network will have an important military role alongside the country's rapidly expanding network of surveillance, imaging and remote sensing satellites.

China routinely denies having military ambitions in space.

Defence Ministry spokesman Yang Yujun on Wednesday dismissed fears the Beidou network would pose a military threat, noting that all international satellite navigation systems are designed for dual civilian and military use.

Catching Up With the U.S.

China accelerated its military satellite research and development after PLA commanders found they were unable to track two U.S. aircraft carrier battle groups deployed in 1996 to the Taiwan Strait at a time of high tension between the island and the mainland, analysts say.

The effort received a further boost when it was shown how crucial satellite networks were in the 1991 Gulf War, the 1999 NATO bombing of Yugoslavia and the 2003 invasion of Iraq.

While China still lags the United States and Russia in overall space technology, over the last decade it has rapidly become a state-of-the-art competitor in space-based surveillance after deploying a range of advanced satellite constellations that serve military and civilian agencies.

With the launch of more than 30 surveillance satellites over the last decade, according to space technology experts, the PLA can monitor an expanding area of the earth's surface with increased frequency, an important element of reliable military reconnaissance.

That coverage gives PLA commanders vastly improved capability to detect and track potential military targets.

Real-time satellite images and data can also be used to coordinate the operations of China's naval, missile and strike aircraft forces in operations far from the mainland.

"What we are seeing is China broadly acquiring the same capabilities in this area as those held by the U.S.," said Ross Babbage, a defence analyst and founder of the Canberra-based Kokoda Foundation, an independent security policy unit.

Getty Images

An upgraded Long March 2F rocket carries the Shenzhou-8 spacecraft at the Jiuquan Satellite Launch Center on October 26, 2011 in Jiuquan, China.


"Essentially, they are making most of the Western Pacific far more transparent to their military."

In a recent article for the Journal of Strategic Studies, researchers Eric Hagt and Matthew Durnin attempted to estimate the capability of China's space network using orbital modeling software and available data on satellite performance.

China's most basic satellites carried electro-optical sensors capable of taking high resolution digital images in the visible and non-visible wavelengths, wrote the authors.

More advanced satellites launched in recent years carried powerful synthetic aperture radars that could penetrate cloud and cover much bigger areas in high detail.

Added to that, China was now deploying satellites that could monitor electronic signals and emissions, so-called electronic intelligence or ELINT platforms, the authors said.

"Next to China, only the United States possesses more capable tactical support systems in space for tactical operations," they wrote.

Copyright 2011 Thomson Reuters. Click for restrictions.

Source: http://www.cnbc.com/id/45820343?__source=RSS*tag*&par=RSS

xbox update xbox update nba schedule nhl realignment nhl realignment kristin chenoweth country music awards

UC Davis Chancellor putting increased emphasis on communications

Just got this email announcement and I thought I would share. ?As many know, in the aftermath of the pepper spray incident, whether you support the UC Davis Chancellor or not, it was pretty clear that communications regarding the incident were, well, poor at best. ?Hopefully this will improve things. ?Of course, action is more important than communication --- but I am glad to see the Chancellor responding to communication issues ---

Dear Colleagues,?
??
I write to inform you about additional actions that I am taking immediately to strengthen Strategic Communications. These steps will help us address needs and challenges facing UC Davis today while preparing us to take advantage of opportunities that lie ahead.?

You may recall that in September 2011 I eliminated the office of Vice Chancellor of University Relations and shifted Communications, Government Relations, and Special Events to the Office of the Chancellor, reporting directly to me. Shortly thereafter, Cynthia Barbera was brought on to serve as the acting Executive Director of Strategic Communications pending the appointment of a permanent director.?
??
In meetings with various colleges and departments over the past three weeks as well as in other contexts, I heard many comments and clearly expressed concerns about the ability of Strategic Communications to meet our present needs. I share many of these concerns.?
??
Accordingly, I have asked Barry Shiller to serve as interim Executive Director of Strategic Communications. He will assume day-to-day management of the campus?s central communications activities, effective January 5, 2012.?
??
Barry brings to us an extensive background in strategic communications, diverse career experiences from the UC system and elsewhere, and ? as a proud Aggie parent (Class of 2007) ? particular appreciation for UC Davis' distinctions and excellence.?
??
Most recently, Barry served for more than three years as the Associate Vice Chancellor for Communications & Marketing at the University of California, Santa Cruz (UCSC). There, he guided UCSC?s marketing and institutional communication efforts including media relations, branding and marketing, and campus communications. He closely collaborated with students, faculty, staff, foundation and alumni representatives, campus leadership and others on a comprehensive effort to highlight UCSC?s many distinctions in teaching, research and service. Under his leadership, UCSC achieved greater regional and national prominence.?
??
Barry previously served in a similar capacity for nearly five years at Saint Mary's College of California. Prior to that, he held communications and public affairs leadership positions at a San Francisco public relations agency; an e-commerce start-up firm and the northern California affiliate of the American Automobile Association (AAA). Barry earned his bachelor?s degree from the University of San Francisco and completed advanced studies in insurance and risk management.?
??
I am confident that Barry will serve us extremely well as the interim leader of our central communications activities. I hope you will join me in warmly welcoming him to the UC Davis family.?
??
It is also essential that we launch and complete a comprehensive national search for the permanent director of our central communications unit. Many faculty and others have expressed an interest in helping to shape and inform the long-term direction of our campus communications activities. Community input will be critical to this search as well as the ongoing evolution of our strategic communications efforts.?
??
I have asked Jessie Ann Owens, Dean of Humanities, Arts and Cultural Studies, to chair the Recruitment and Selection Committee for this important position, and Dean Owens has graciously agreed. You may expect details early in the New Year about the search process and in particular how faculty, students, staff and other members of the campus community can contribute to this endeavor.?
??
I?ll continue to share updates as we work to improve our communications efforts. Your assistance is critical to our success.?
??
I wish each of you much peace as we enter the New Year.?
??
Sincerely,?
Linda P.B. Katehi?
Chancellor

Source: http://phylogenomics.blogspot.com/2011/12/uc-davis-chancellor-putting-increased.html

remember the titans wale wale weather denver weather denver ambition dorothy rodham

Friday, December 30, 2011

What issues did Dwight D Eisenhower faced when he was president?

Why do we need your email address?

We will use your email address to send you updates (if you request them) about questions you ask, answer or track, and to help you retrieve your password if you forget it.

Your email address will not be used for any other purpose without your permission.

Already have an Answers.com account? Connect your accounts!

By doing so, you include all of your history (contributions, messages, profile) from your Answers.com account in your Facebook account.

If you don't connect accounts, your new account will be starting from scratch.

Source: http://wiki.answers.com/Q/What_issues_did_Dwight_D_Eisenhower_faced_when_he_was_president

chris carpenter the brothers grimm the brothers grimm penn state football weather boston grimm fairy tales grimm fairy tales

U.S. says China is not a currency manipulator (Reuters)

WASHINGTON (Reuters) ? The U.S. Treasury again shied away from labeling China a currency manipulator on Tuesday, but it rapped the country for not moving fast enough on exchange rate reforms.

Some U.S. politicians have argued that China has gained an unfair competitive edge in global markets by keeping the yuan artificially low to boost exports.

But the Treasury, in a semi-annual report, said that statutes covering a designation of currency manipulator "have not been met with respect to China."

Even so, Treasury said appreciation in the yuan has been too slow. The value of the yuan, which Beijing manages closely, has risen by 4 percent against the dollar this year and 7.7 percent since China dropped a firm peg against the greenback in June 2010.

"The movement of the (yuan) to date is insufficient," the Treasury said in a statement following the release of its semi-annual report to Congress on international economic and exchange rate policies.

"Treasury will closely monitor the pace of appreciation and press for policy changes that yield greater exchange rate flexibility, a level playing field, and a sustained shift to domestic demand-led growth."

The Peterson Institute for International Economics recently estimated the yuan was undervalued by 24 percent against the dollar, down from 28 percent earlier in the year. It attributed the change to both Beijing's policy of gradual currency appreciation and higher Chinese inflation.

MORE OF THE SAME

Treasury Secretary Timothy Geithner has said the law that requires the administration to determine whether U.S. trade partners are deliberately undervaluing their currencies is a poor tool to push Beijing on the yuan.

Instead, the United States has tried to use international economic fora, such as the Group of 20 leading nations and the International Monetary Fund, to ramp up pressure on Beijing to move more quickly to a more-flexible currency.

"It's not very surprising. It's sort of sliding it in under the radar. They're (Treasury) really not in a position to make any major moves at this point," said Sean Incremona, an economist at 4Cast in New York.

The Treasury Department has not labeled country a currency manipulator since July 1994, when it cited China. A designation would require the United States to step up negotiations with Beijing on the yuan's value.

The yuan slipped on Tuesday as strong dollar demand from corporations offset a record high mid-point fixed by the People's Bank of China. The central bank set an all-time high dollar/yuan mid-point in an apparent hope to let the yuan rise a little more at the end of 2011 so as to make the yuan's full-year nominal appreciation look bigger, traders said.

(Additional reporting by Luciana Lopez; Editing by Leslie Adler)

Source: http://us.rd.yahoo.com/dailynews/rss/china/*http%3A//news.yahoo.com/s/nm/20111227/bs_nm/us_usa_china_currency

the duchess hope solo hope solo texas high school football fugazi fugazi indiana jones and the last crusade

M 1.5, San Francisco Bay area, California

Magnitude1.5Date-TimeLocation37.326?N, 122.108?WDepth0.1 km (~0.1 mile) (poorly constrained)RegionSAN FRANCISCO BAY AREA, CALIFORNIADistances
  • 5 km (3 miles) SSW (192?) from Los Altos, CA
  • 6 km (4 miles) SSE (153?) from Los Altos Hills, CA
  • 6 km (4 miles) W (279?) from Cupertino, CA
  • 9 km (6 miles) SW (235?) from Sunnyvale, CA
  • 19 km (12 miles) W (265?) from San Jose City Hall, CA
Location Uncertaintyhorizontal +/- 0.3 km (0.2 miles); depth +/- 0.9 km (0.6 miles)ParametersNph= 11, Dmin=2 km, Rmss=0.1 sec, Gp=112?,
M-type=duration magnitude (Md), Version=0SourceEvent IDnc71701820

Source: http://earthquake.usgs.gov/earthquakes/recenteqsus/Quakes/nc71701820.php

north korea news patrick willis team america snow day snow day ryan braun neti pot

Thursday, December 29, 2011

Rangers Vs. Capitals Final Score: Washington Handles New York, 4-1

The Washington Capitals ended the first period with the New York Rangers tied 1-1, with Caps Marcus Johansson striking first blood, assisted by Jeff Halpern. The Rangers quickly answered back with a goal of their own by Brandon Dubinsky however, assisted by Ryan Callahan, to tie the game.

The Caps pulled away in the second period however, thanks to goals by Troy Brouwer and Alexander Semin to take a 3-1 lead. Early in the third period the Caps put the nail in the coffin when Alexander Semin picked up his second goal of the game, assisted by Alex Ovechkin and Karl Alzner. On the night in the 4-1 victory, Tomas Vokoun saved 32 of 33 shots on goal.

We'll have more on this game throughout the day on SB Nation D.C., but for more on the matchup you can check out the NHL hub on SB Nation. For more on all things Capitals head over to our Japers' Rink blog. For some perspective from the other side of the ice, head over to Blueshirt Banter.

Source: http://dc.sbnation.com/washington-capitals/2011/12/28/2667387/rangers-vs-capitals-final-score-washington-handles-new-york-4-1

asteroid eric johnson eric johnson russell pearce russell pearce emergency alert system chelsea handler

Wednesday, December 28, 2011

Texas men trade same Christmas card for decades

WHITEHOUSE, Texas (AP) -- A Christmas card that crisscrossed the country as part of an old joke between two Texas men will rest this holiday for the first time in 61 years.

Acker Hanks mailed the card to his former neighbor Lee Kelley in 1950. Kelley, a prankster, mailed it back a year later.

The two continued sending the card back and forth, and when Kelley died, his widow mailed the tattered message for over a decade. Last year, it returned to Hanks unread. He believes Kelley's widow moved to a nursing home.

A list of dates and places in the worn card documents its journey. Hanks plans to frame it.

"I always looked forward to getting the card," he told the Tyler Morning Telegraph (http://bit.ly/vbaPyB ). "I don't think it'll ever leave me now."

---

Information from: Tyler Morning Telegraph, http://www.tylerpaper.com

Source: http://hosted.ap.org/dynamic/stories/U/US_ODD_WELL_TRAVELED_CHRISTMAS_CARD?SITE=AP&SECTION=HOME&TEMPLATE=DEFAULT

jim thome fun fun fun fest fun fun fun fest move your money alabama vs lsu alabama vs lsu robert schuller

Libya to include rebels in military from January (Reuters)

TRIPOLI (Reuters) ? Libya will include thousands of former rebels who helped topple Muammar Gaddafi in its armed forces from January, the defense minister said on Sunday, testing the government's ability to get rebel leaders to cede command of their fighters.

Although rebels met a deadline imposed by the National Transitional Council (NTC) to withdraw this week from the capital Tripoli, militias led by rival commanders still guard key installations and checkpoints across the city.

The lack of a fully functioning army and police force, has given militias free rein to fight turf wars after the uprising that ended Gaddafi's 42-year dictatorship in August.

"The program aims at including the revolutionaries in many fields including defense," Osama al-Juwali, interim defense minister told a news conference also attended by interim interior minister Fawzi Abd al-All.

"The idea is to inject new blood in the army which was marginalized by the tyrant (Gaddafi)," said Juwali who was commander of the Zintan militia that captured Gaddafi's son Saif al-Islam in November.

Abd al-All said the rebels were also invited to take up positions in the interior ministry which, he said, was understaffed. He said they could also apply for civilian jobs in government offices through the ministry of labor.

Lifting of the U.N. Security Council sanctions this month on Libya's central bank and a subsidiary means that the interim leaders have access to cash that could be used to offer the fighters well-paying government jobs.

Juwali said that part of the plan was to train the rebels to take up high-ranking positions in the military.

He said it would take a month to register and allocate them to the military, police and other civilian posts, and months before they were trained to guard borders and installations, including oilfields and refineries, now held by rival militias.

"Everyone is allowed to join the special forces, the navy and others," he said. Talks were being held with a number of countries to train rebels inside and outside Libya for the military, he said.

Gaddafi ignored the military, giving control to security militias led by either his sons or confidants.

Juwali said he was not concerned about occasional skirmishes among rebel factions and that he was continuously in contact with most of the rebel leaders.

"I am not worried about the revolutionaries," he told Reuters after the conference. "The revolutionaries ask me every day when can they hand in their weapons and ammunition, but I tell them to wait until we have the facilities to store them."

The latest major turf war broke out this month when armed men in the vehicles of Libya's new national army tried to take control of Tripoli's international airport from a powerful Zintan militia unit.

(Editing by Louise Ireland)

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/nm/20111225/wl_nm/us_libya_rebels

houston astros matt barnes sexiest man alive 2011 ruben studdard ruben studdard black friday sales 2011 black friday sales 2011

abclive: ABC Live Reports: Rural India Needs Active and Voluntary Participation of Young Doctors http://t.co/mVMw1HOK

  • Passer la navigation
  • Twitter sur votre mobile ? Cliquez ici m.twitter.com!
  • Passer cette ?tape
  • Connexion
Loader Twitter.com
  • Connexion
ABC Live Reports: Rural India Needs Active and Voluntary Participation of Young Doctors goo.gl/fb/RcGrm abclive

ABC Live

Pied de page

Source: http://twitter.com/abclive/statuses/151344655798251520

billy the kid safe and sound botticelli x factor winner footlocker julia gillard julia gillard

Tuesday, December 27, 2011

12/28/2011 - University Closure ? Holiday Break

  • Use the Custom Filter tool to browse events from multiple categories.

There are currently no Featured Events.

The event you are looking for cannot be found. To find more events, you can:

  1. Switch your view to either Day, Week, or Month.
  2. Navigate to the previous or next Day/Week/Month using the Previous/Next links above.
  3. Click on a highlighted day from the mini calendar in the sidebar.
  4. Click here to submit your own events.

Source: http://events.ua.edu/events/index.php?com=detail&eID=1506

kris jenner kris jenner livestand power ball kelly slater kelly slater palindrome

A Song from Hugh Jackman -- In Chinese!

Hugh Jackman, the guest on Friday's "Anderson," has been spending a lot of time in New York City lately, due to his starring role in the one-man Broadway show, "Hugh Jackman: Back on Broadway."
?
This is not Hugh's first experience singing. He has been on Broadway twice before, and he even sang in a foreign language for a cameo in a film. "I played a nightclub owner who likes to occasionally get up and sing songs? the director said you should actually sing in Chinese? it took me two months to learn that song!"
?
Hugh still remembers that song, and he sings it for the "Anderson" audience.

Source: http://www.andersoncooper.com/2011/11/17/a-song-from-hugh-jackman-in-chinese/

lance ball kansas city chiefs tom brady packers green bay packers tim tebow chiefs

Monday, December 26, 2011

Commentary: NCAA, Ohio St., both to blame

By Brian Kollars, Staff Writer Updated 1:15 PM Sunday, December 25, 2011

The in-laws came up huge with an amazing gift. If you drive past our house, you?ll see a small leg lamp in the window, a replica of the cussing dad?s big prize in ?A Christmas Story.? Our teenager is appalled that I would display this fine piece of craftsmanship in such a prominent space but, hey, she doesn?t pay the mortgage.

Ohio State football fans got a big lump of coal last week when the NCAA surprised everyone by banning the Buckeyes from a bowl game ... next season. There?s no way the fallout from Jim Tressel?s dirty little secret should stretch into 2012. But it will.

The NCAA allegedly employs bright people who could consult a calendar and figure out that Ohio State was in line for a bowl game this year. Why not step up the pace and drop this bombshell a month earlier? That way, OSU doesn?t go to a meaningless bowl game this season.

On the other hand, the arrogant OSU administration has fumbled at every turn, from the ridiculous news conference during which Tressel was given a big smooch to the weak self-imposed sanctions. If there was any hint of this coming down, OSU should have said no to the Gator Bowl.

I?m sure the attorneys are drawing up Gene Smith?s golden parachute right now.

The NBA tips off today after what seemed like a three-day exhibition season. The most intriguing story line is not the status of Kobe Bryant?s wrist or why Mariah Carey is not part of the league?s marketing plan.

The big question: How long will it take Jack Nicholson to snub the Lakers for the Clippers?

Jill sent me to that fancy new Kroger store in Kettering two days before Christmas. I?m sure she was laughing, but I survived my first trip to the store despite the hand-to-hand combat in the baking goods aisle.

A big thanks to Mary, who checked me out. She asked if I had a Kroger card and my reply was a blank stare. She told me to punch in my phone number, which led to 22 bucks of savings!

Merry Christmas to all of you vociferous readers. We?ll return next week with some New Year?s resolutions for athletes, etc. If you have any suggestions, send them my way and I?ll give you credit for your clever ideas.

Contact this reporter at (937) 225-2163 or bkollars@DaytonDailyNews.com.

Source: http://www.middletownjournal.com/middletown-sports/commentary-ncaa-ohio-st-both-to-blame-1304031.html?cxtype=rss_sports

rhodes scholar cranberry sauce recipe mls cup amas 2011 black friday elliot elliot

Mexican army: 'El Chapo' security head arrested (AP)

MEXICO CITY ? The Mexican army announced Sunday that it had captured the head of security for Sinaloa drug cartel head Joaquin "El Chapo" Guzman, one of the world's most wanted men.

The suspect, who was not identified by name, was captured in the Sinaloa state capital of Culiacan and will be presented to the media Monday morning, the army said.

Guzman, Mexico's top drug lord, is one of the world's richest men, and has eluded authorities by moving around and hiding since his 2001 escape from prison in a laundry truck.

The army said the man they had arrested also ran cartel activities in Durango and southern Chihuahua state, and was responsible for carrying out secret burials of cartel victims, kidnapping, extortion and arson. They did not say if the arrest moved the military closer to capturing Guzman, an arrest that would be seen as a major victory for the government of President Felipe Calderon.

Guzman is worth more than $1 billion, according to Forbes magazine, which has listed him among the "World's Most Powerful People." He has a $7 million bounty on his head, and thousands of law enforcement agents from the U.S. and other countries working on capturing him.

His cartel controls cocaine trafficking on the Mexican border with California and has moved eastward to the corridor between the Mexican state of Sonora, which borders Arizona.

Separately, Mexican soldiers discovered 13 bodies in an abandoned truck Sunday along with a message that they were killed in a war between rival drug cartels in the eastern state of Veracruz, officials said.

The bodies were found in Tamaulipas state, a few hundred yards (meters) from its border with Veracruz, according to the Tamaulipas attorney general's office. The office said that 10 of the bodies had been decapitated.

The area has been the scene of bloody battles between the Gulf and Zetas cartels, and a pair of banners alluding to a rivalry were found in the truck, the statement from the attorney-general's office said.

On Friday, the attorney general's office in Veracruz said it had found 10 bodies in a different area along the border with Tamaulipas after receiving a tip.

On Thursday, three U.S. citizens traveling to spend the holidays with their relatives in Mexico were among those killed in a spree of shooting attacks on buses. In the spree, a group of gunmen attacked three buses in Veracruz, killing a total of seven passengers.

The Americans killed were a mother and her two daughters who were returning to visit relatives in the region.

The five gunmen who allegedly carried out the attacks were later shot to death by soldiers.

Earlier, the gunmen also killed four people in the nearby town of El Higo, Veracruz.

Local police in Veracruz have become so corrupt that on Wednesday the government decided to dissolve the entire force in the state's largest city, also known as Veracruz, and sent the Navy in to patrol. Some 800 police officers and 300 administrative employees were laid off.

Source: http://us.rd.yahoo.com/dailynews/rss/mexico/*http%3A//news.yahoo.com/s/ap/20111226/ap_on_re_la_am_ca/lt_drug_war_mexico

kara dioguardi thomas kinkade the shining stanford stanford when does daylight savings time end world series mvp

Sunday, December 25, 2011

148Apps: How To Use That New iPhone, iPad, and iPod Touch - http://t.co/Sy40DVF6 - quick help guide to get the most from your new iOS device!

  • Passer la navigation
  • Twitter sur votre mobile ? Cliquez ici m.twitter.com!
  • Passer cette ?tape
  • Connexion
Loader Twitter.com
  • Connexion
How To Use That New iPhone, iPad, and iPod Touch - tpga.me/shWWfl - quick help guide to get the most from your new iOS device! 148Apps

Pied de page

Source: http://twitter.com/148Apps/statuses/150992396509917184

christina aguilera tony stewart amas music awards 2011 music awards 2011 jill biden jill biden

QUAthletics: Marquis Barnett Featured In Christmas Day Edition Of Hartford Courant: Quinnipiac University men's basketball st... http://t.co/5Apy6HJG

  • Passer la navigation
  • Twitter sur votre mobile ? Cliquez ici m.twitter.com!
  • Passer cette ?tape
  • Connexion
Loader Twitter.com
  • Connexion
Marquis Barnett Featured In Christmas Day Edition Of Hartford Courant: Quinnipiac University men's basketball st... bit.ly/tIREHB QUAthletics

Quinnipiac Athletics

Pied de page

Source: http://twitter.com/QUAthletics/statuses/150959326473879552

verlander justin verlander pepper spraying cop pepper spraying cop somaya reece padma lakshmi juelz santana

Iowa Leader Mired in Controversy After Backing Santorum (ABC News)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/178375074?client_source=feed&format=rss

sugar cookie recipe sugar cookie recipe robert deniro how the grinch stole christmas macaroni and cheese festivus festivus

Iran navy starts 10-day wargame in Strait of Hormuz (Reuters)

TEHRAN (Reuters) ? Iran began 10 days of naval exercises in the Strait of Hormuz on Saturday, raising concern about a possible closure of the world's most strategic oil transit channel in the event of any outbreak of military conflict between Tehran and the West.

The military drill, dubbed "Velayat-e 90," comes as the tension between the West and Iran is escalating over the Islamic state's nuclear program.

Some analysts and diplomats believe the Islamic Republic could try to block the strait in the event of any war with the West over suspicions it is seeking atom bombs. Iran's arch-foes Israel and the United States have not ruled out military action if diplomacy and sanctions fail to rein in Iran's nuclear work.

Iran says it wants nuclear energy only for peaceful ends.

"The enforcement of the decision to close of the Strait of Hormuz is certainly within Iran's armed forces' capability, but such a decision should be made by the country's top authorities," Iranian Navy commander Habibollah Sayyari was quoted as saying by the semi-official ILNA labor news agency.

Iran has said in the past that it would respond to any attack by targeting U.S. interests in the region and Israel, as well as closing the strait, the only access channel for eight U.S.-aligned, Gulf Arab states to foreign markets.

Iranian authorities have given no indication the strait will be closed during the exercise, and it has not been shut during previous drills.

"Displaying Iran's defensive and deterrent power as well as relaying a message of peace and friendship in the Strait of Hormuz and the free waters are the main objectives of the drill," Sayyari said.

"It will also display the country's power to control the region as well as testing new missiles, torpedoes and weapons."

"Velayat" is a Persian word for "supremacy" and it is currently used as a title of deference for the Supreme Leader Ayatollah Ali Khamenei.

The United States, Britain and Canada announced new measures against Iran's energy and financial sectors last month and the European Union is considering a ban - already in place in the United States - on imports of Iranian oil.

(Writing by Ramin Mostafavi; Editing by Alison Williams)

Source: http://us.rd.yahoo.com/dailynews/rss/iran/*http%3A//news.yahoo.com/s/nm/20111224/wl_nm/us_iran_navy_wargame

sugar bowl kourtney kardashian pregnant kourtney kardashian pregnant wormwood bcs bowl games jose reyes capital one bowl

radicalmedia: Awe. Justina, you look great in Vogue Japan! http://t.co/qAqVWNaG

  • Passer la navigation
  • Twitter sur votre mobile ? Cliquez ici m.twitter.com!
  • Passer cette ?tape
  • Connexion
Loader Twitter.com
  • Connexion
Awe. Justina, you look great in Vogue Japan! twitpic.com/7ww0eq radicalmedia

Pied de page

Source: http://twitter.com/radicalmedia/statuses/149982124005535744

vincent jackson veterans day paterno oakland raiders carson palmer al davis edmund fitzgerald

(Merry) Christmas Disease

An old post but a good one for Christmas time. This previously appeared on my blog when it lived at fieldofscience.com. I hope you enjoy and I wish you a very Merry Christmas.

ResearchBlogging.orgSo I was feeling a little lazy and thought I should find a disease related to Christmas, that way it?d be topical and I?d look like a genius. Well maybe not a genius, as all I did was type ?Christmas? and ?disease? into google and it returned ?Christmas disease?. Don?t worry though, the disease itself is pretty cool!

Contrary to popular belief Christmas disease is not limited to public drunkenness

Unfortunately for me my attempt at topical blogging reveals that?Christmas disease is not named after the holiday but instead after?Mr Stephen Christmas, a British migrant? who immigrated to Canada, who was diagnosed at the age of 2 in 1949 with haemophilia. On a return visit to England in 1952 Stephen was again hospitalised and a sample of his blood was sent away to the Oxford Haemophilia Centre where it was determined by Rosemary Biggs and R.G. McFarlane that Mr. Christmas did not have a normal case of haemophilia, he had something that had never been described before.

Haemophilia is best described as a blood clotting disease. All haemophilia cases are genetic and are inherited from your parents and although there are many types the risk is that any blood vessel breakage could result in ?bleeding out? as suffers are unable to clot or coagulate normally so the blood keeps spilling.

The proteins responsible for allowing the blood to clot are called ?Factors? and there are 3 that are particularly important yet unhelpfully named as Factor VIII, IX and XI.

Haemophilia C is caused by a genetic mutation that produces a non-functional?Factor XI, a.k.a. plasma thromboplastin antecedent. The gene for Factor XI is carried on chromosome 4, which makes it a?recessive autosomal disease. All that means is that there is an equal chance for both males and females to get it and for the full blown disease you need to inherit dodgy copies of the gene from both parents but an intermediate form of the disease can still occur if you receive only one dodgy copy. For this reason it is super rare making up about 1% of all haemophilia cases but in small groups where children are encouraged to marry and have children with others from inside the same group, say for example?Ashkenazi Jews where C type Haemophilia affects 8% of the population, the proportyion of type C haemophilia cases goes up.

The genetic mutation for types A and B haemophilia are located on the?X chromosome so are classified as X-linked disorders rather than an autosomal disorder like type C. This means the disease is more common, and often more serious, in males. The reason for this disparity is that males only have one X chromosome (remember males are XY at their sex chromosomes) while females have two X?s. One dodgy copy of a gene in an X chromosome in males = disease whereas females can in most cases accommodate one dodgy copy and still be fine.

Type A is the most common form of haemophilia accounting for 80% of all cases and is caused by a mutation destroying the activity of?Factor VIII, a.k.a. anti-haemophilic factor. Factor VIII forms a complex with other clotting factors in the presence of high calcium concentration that result in a clotting cascade. For those of you with a bit of biology background you will know that Ca is not present in high concentrations anywhere in the body (except the bone)?because it is biologically active and so its presence is a potent signal. Nerves use Ca during signalling, immune cells can follow a Ca gradient and other cells use it to talk to each other. Anyway when the concentration that is free in the blood goes up it indicates blood vessel damage and initiates the clotting cascade through activation of Factor VIII.

Finally we work our way back to Stephen Christmas. When the scientists at the Oxford Haemophilia Centre looked they found levels of Factor VIII? was fine (at this stage type C hadn?t been discovered so Factor XI wasn?t analysed) but Stephen was lacking Factor IX. This type of Haemophilia was classed type B.

Type B haemophilia is X-linked and here the mutation breaks?Factor IX, a.k.a. Christmas Factor, that acts as a?serine protease. The activity of Factor IX is controlled by either XI or VIII as either can cut Factor IX in half which converts it from an inactive to active form. The cut or cleaved form of Factor IX also requires high Ca to function and in the right conditions will promote coagulation. Stephen Christmas? condition was treated using transfusions of normal blood which contained normal Factor IX allowing him to clot normally but repeated transfusions in the early 60?s and 70?s resulted in him eventually contracting Human Immuno-deficiency Virus (HIV) which later developed into Auto Immune-deficiency Syndrome (AIDS) which he succumbed to in 1993.

Following the detection of HIV in Stephen?s body he became an active worker and proponent for screen of donated blood to increase the safety of transfusions, which was eventually adopted by1985.

Stephen Christmas was kept alive by transfusions from blood donors and I implore you to give blood as well. Click here for your closest Australian donation centre and just Google for other countries. Best. Gift. Ever.

While Stephen Christmas? life may have been afflicted by a horrible disease his gift was to help bring in an era of change that has undoubtedly saved millions of lives by screening donor blood for harmful elements, including HIV Hepatitis B and C viruses amongst many others.

Fun facts!!!

Type B haemophilia is the form that ran/runs in both the British and Russian royal families!

Christmas Disease is cause for a deficiency in functional Factor IX resulting in an inability to clot. Over production of Factor IX can be just as bad though and has in fact been linked to conditions such as?deep vein thrombosis which are characterised by inappropriate and unnecessary clotting.

And with that I say have a great holiday period for those of you who are celebrating one and I will be back in the new year after taking a short break to socialise with others in meat-space. Have a good, fun and most importantly safe time and I?ll see you again real soon.

James out.

References

Rogaev EI, Grigorenko AP, Faskhutdinova G, Kittler EL, & Moliaka YK (2009). Genotype analysis identifies the cause of the ?royal disease?.?Science (New York, N.Y.), 326?(5954) PMID:?19815722
BIGGS R, DOUGLAS AS, MACFARLANE RG, DACIE JV, PITNEY WR, & MERSKEY (1952). Christmas disease: a condition previously mistaken for haemophilia.?British medical journal, 2(4799), 1378-82 PMID:?12997790

Source: http://rss.sciam.com/click.phdo?i=a2416cf372f3c7970c8a26c4831f39cc

hedy lamarr bill conlin clippers kendall jenner plane crash plane crash kardashian christmas card

Saturday, December 24, 2011

Enzyme that flips switch on cells' sugar cravings could be anti-cancer target

Enzyme that flips switch on cells' sugar cravings could be anti-cancer target [ Back to EurekAlert! ] Public release date: 22-Dec-2011
[ | E-mail | Share Share ]

Contact: Lynne Anderson
virginia.l.anderson@emory.edu
404-778-5452
Emory University

Cancer cells tend to take up more glucose than healthy cells, and researchers are increasingly interested in exploiting this tendency with drugs that target cancer cells' altered metabolism.

Cancer cells' sugar cravings arise partly because they turn off their mitochondria, power sources that burn glucose efficiently, in favor of a more inefficient mode of using glucose. They benefit because the byproducts can be used as building blocks for fast-growing cells.

Scientists at Winship Cancer Institute of Emory University have shown that many types of cancer cells flip a switch that diverts glucose away from mitochondria. Their findings suggest that tyrosine kinases, enzymes that drive the growth of several types of cancer, play a greater role in mitochondria than previously recognized.

The results also highlight the enzyme PDHK (pyruvate dehydrogenase kinase) as an important point of control for cancer cell metabolism.

The results were published online Thursday by the journal Molecular Cell. http://www.cell.com/molecular-cell/

Video available at http://www.youtube.com/watch?v=G1hUSiXISYs

"We and others have shown that PDHK is upregulated in several types of human cancer, and our findings demonstrate a new way that PDHK activity is enhanced in cancer cells," says Jing Chen, PhD, associate professor of hematology and medical oncology at Emory University School of Medicine and Winship Cancer Institute. "PDHK is a very attractive target for anticancer therapy because of its role in regulating cancer metabolism."

Chen and Sumin Kang, PhD, assistant professor of hematology and medical oncology at Emory University School of Medicine, are co-corresponding authors. Postdoctoral fellows Taro Hitosugi, Jun Fan and Tae-Wook Chung are co-first authors of the paper. Co-authors at Emory include Georgia Chen, PhD, Sagar Lonial, MD, Haian Fu, PhD, and Fadlo Khuri, MD. Collaborators at Yale University, Novartis and Cell Signaling Technology contributed to the paper.

Chen and his colleagues started out studying the tyrosine kinase FGFR1, which is activated in several types of cancer. Tyrosine kinases attach a phosphate to other proteins, making them more or less active. They found that FGFR1 activates the enzyme PDHK, which has a gatekeeper function for mitochondria.

"We used FGFR1 as a platform to look at how metabolic enzymes are modified by oncogenic tyrosine kinases," Chen says. "We discovered that several oncogenic tyrosine kinases activate PDHK, and we found that many of those tyrosine kinases are found within mitochondria."

This was a surprise because tyrosine kinases are usually thought to drive growth by being active next to the cell membrane, Chen says.

Introducing a form of PDHK that is insensitive to tyrosine kinases into human cancer cells forces the cells to grow more slowly and form smaller tumors in mice, they found. This indicates that PDHK could be a target for drugs that specifically target cancer cells' altered metabolism.

The experimental drug dichloroacetate (DCA), which inactivates PDHK, is being used in new clinical trials for cancer. Chen is collaborating with Haian Fu, professor of pharmacology and director of the Emory Chemical Biology Discovery Center, to find other, more potent inhibitors of PDHK.

###

The research was supported by the National Cancer Institute.

Reference:

T. Hitosugi et al. Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism. Mol Cell (2011).


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Enzyme that flips switch on cells' sugar cravings could be anti-cancer target [ Back to EurekAlert! ] Public release date: 22-Dec-2011
[ | E-mail | Share Share ]

Contact: Lynne Anderson
virginia.l.anderson@emory.edu
404-778-5452
Emory University

Cancer cells tend to take up more glucose than healthy cells, and researchers are increasingly interested in exploiting this tendency with drugs that target cancer cells' altered metabolism.

Cancer cells' sugar cravings arise partly because they turn off their mitochondria, power sources that burn glucose efficiently, in favor of a more inefficient mode of using glucose. They benefit because the byproducts can be used as building blocks for fast-growing cells.

Scientists at Winship Cancer Institute of Emory University have shown that many types of cancer cells flip a switch that diverts glucose away from mitochondria. Their findings suggest that tyrosine kinases, enzymes that drive the growth of several types of cancer, play a greater role in mitochondria than previously recognized.

The results also highlight the enzyme PDHK (pyruvate dehydrogenase kinase) as an important point of control for cancer cell metabolism.

The results were published online Thursday by the journal Molecular Cell. http://www.cell.com/molecular-cell/

Video available at http://www.youtube.com/watch?v=G1hUSiXISYs

"We and others have shown that PDHK is upregulated in several types of human cancer, and our findings demonstrate a new way that PDHK activity is enhanced in cancer cells," says Jing Chen, PhD, associate professor of hematology and medical oncology at Emory University School of Medicine and Winship Cancer Institute. "PDHK is a very attractive target for anticancer therapy because of its role in regulating cancer metabolism."

Chen and Sumin Kang, PhD, assistant professor of hematology and medical oncology at Emory University School of Medicine, are co-corresponding authors. Postdoctoral fellows Taro Hitosugi, Jun Fan and Tae-Wook Chung are co-first authors of the paper. Co-authors at Emory include Georgia Chen, PhD, Sagar Lonial, MD, Haian Fu, PhD, and Fadlo Khuri, MD. Collaborators at Yale University, Novartis and Cell Signaling Technology contributed to the paper.

Chen and his colleagues started out studying the tyrosine kinase FGFR1, which is activated in several types of cancer. Tyrosine kinases attach a phosphate to other proteins, making them more or less active. They found that FGFR1 activates the enzyme PDHK, which has a gatekeeper function for mitochondria.

"We used FGFR1 as a platform to look at how metabolic enzymes are modified by oncogenic tyrosine kinases," Chen says. "We discovered that several oncogenic tyrosine kinases activate PDHK, and we found that many of those tyrosine kinases are found within mitochondria."

This was a surprise because tyrosine kinases are usually thought to drive growth by being active next to the cell membrane, Chen says.

Introducing a form of PDHK that is insensitive to tyrosine kinases into human cancer cells forces the cells to grow more slowly and form smaller tumors in mice, they found. This indicates that PDHK could be a target for drugs that specifically target cancer cells' altered metabolism.

The experimental drug dichloroacetate (DCA), which inactivates PDHK, is being used in new clinical trials for cancer. Chen is collaborating with Haian Fu, professor of pharmacology and director of the Emory Chemical Biology Discovery Center, to find other, more potent inhibitors of PDHK.

###

The research was supported by the National Cancer Institute.

Reference:

T. Hitosugi et al. Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism. Mol Cell (2011).


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-12/eu-etf122211.php

childish gambino chris hansen sandusky interview with bob costas sandusky interview with bob costas live oak mark kelly mark kelly

MSI unveils gaming notebook with Intel Core i7 CPU






Press release; Joseph Tsai, DIGITIMES?[Thursday 22 December 2011]

Micro-Star International (MSI) has announced its latest gaming notebook - GT780DX, featuring quad-core Intel Core i7 CPU and the latest Nvidia GeForce GTX 570M discrete graphics card that is equipped with 3GB of GDDR5 display memory.

The machine is also equipped with 32GB of DDR3 memory and RAID 0-based accelerated dual hard disk architecture for its hard drive system to allow storage capacity to double and read-write speed to increase by 70%, the vendor said.

Meanwhile, MSI also adds its Turbo Drive Engine (TDE) technology to the machine to ramp up its overall performance. To quickly cool down the system to maintain its stability, MSI also has Cooler Boost technology.

MSI GT780DX notebook specifications

Item

Detail

CPU

Intel Core i7 processor

OS

Windows 7 Ultimate/Professional/Home Premium

Memory

DDR3 up to 32GB

Display

17.3-inch Full HD

Graphics

Nvidia GeForce GTX 570M / 3GB GDDR5

Video Output

1x HDMI, 1x VGA

HDD

750GB SATA 7200rpm + Intel 120GB SSD or

500GB SATA 7200rpm + Intel 120GB SSD or

750GB (4K sector) x2 or

750GB SATA 7200rpm x2 or

500GB SATA 7200/5400rpm x2

ODD

Blu-ray / DVD Super Multi

Interfaces

2x USB 3.0, 3x USB 2.0, 1x eSATA,

SD(XC/HC)/MMC/MS(PRO)/xD card reader

Sound

Sound by Dynaudio, THX TruStudio Pro

Dimension (WxDxH)

428 x 288 x 55mm

Weight

3.9Kg (w/ Battery)

Other Features

Keyboard by SteelSeries

TDE (Turbo Drive Engine)

Cooler Boost

Source: Company, compiled by Digitimes, December 2012

MSI GT780DX notebook

MSI GT780DX notebook
Photo: Company

Categories: Portable Systems

Tags: Core i7 CPU gaming Intel MSI notebook press release product

Topics: Taiwan notebook ODMs Hot Systems Supply chain window

Companies: Micro-Star International

Source: http://www.digitimes.com/news/a20111222PR201.html

the muppets percy harvin percy harvin best cyber monday deals best cyber monday deals cyber monday grover norquist